Immunovaccine and UConn Health Extend Collaboration to Support Advancement of Patient-Specific Immunotherapies to the Clinic
Epitopes are the part of the biological molecule that is the target of an immune response. Neoepitopes are the mutated proteins produced by a patient's own tumors.1
“The potential of neoepitope-based therapies to trigger anti-cancer immune responses tailored to the unique biology of each patient’s disease could be an oncology treatment game-changer,” said Frederic Ors, Immunovaccine’s Chief Executive Officer. “Our successful preclinical work showed that the DPX-NEO delivery formulation is poised to become a significant solution to the barriers that have, thus far, hindered the deployment of these truly personalized immunotherapies on a wide-scale basis. Namely, DPX-NEO’s intrinsic mechanism of action has consistently demonstrated the ability to generate long-lasting T cell responses, and efficiently accommodate a large, diverse band of peptide targets, both of which may be crucial to generating sustained, impactful anti-tumor activity.”
In previously announced preclinical research, researchers from
“The successful results from our work in mouse models, combining our proprietary neoepitope selection process, along with the DepoVax-based formulation technologies, strongly support advancement into a clinical program. My colleagues and I look forward to doing so,” said Principal Investigator
The technology underlying DepoVax formulations suspends active components in an oil diluent that prevents their release at the site of injection. This process forces immune cells to take up these components in an active process, delivering them directly to immune organs such as the lymph nodes. DepoVax formulations have undergone extensive testing in more than 60 preclinical and seven clinical studies. In clinical trials, these formulations have consistently demonstrated the ability to generate robust T and B cell responses, and durable immune responses.
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1 Neoepitope Vaccines, Next Immunotherapy Frontier Cancer Discovery Published Online First
Source: Immunovaccine Inc.